Type 1 Diabetes: Côte d’Azur Health Research Takes Center Stage

DiogenX, the biotechnology company co-founded by Professor Patrick Collombat, Inserm research director at the Institute of Biology Valrose in Nice, has recently raised 27.5 million euros to advance its regenerative treatment for type 1 diabetes towards clinical development.

The research efforts are hosted in Nice at the renowned and internationally acclaimed Institute of Biology Valrose (iBV), a tripartite institute comprising the CNRS (French National Centre for Scientific Research), Inserm (National Institute of Health and Medical Research), and the University Côte d’Azur.

New investors, including Roche Venture Fund, Eli Lilly and Company, and Omnes, have joined the ranks of existing investors such as Boehringer Ingelheim Venture Fund (BIVF), JDRF T1D Fund, and AdBio partners in this funding round. This funding round will enable the advancement of DiogenX’s leading drug candidate into clinical development for patients with type 1 diabetes. DiogenX had previously raised 4.5 million euros in June 2020.

The flagship program of DiogenX has the potential to become the first treatment capable of modifying the course of pathology in symptomatic type 1 diabetes.

Founded in 2020 based on the research work of Patrick Collombat, one of the leading scientists in the field of pancreatic beta cell regeneration, DiogenX is developing first-in-class recombinant proteins designed for the treatment of type 1 diabetes.

The main program of DiogenX aims to regenerate insulin-producing pancreatic beta cells using a recombinant protein that modulates the Wnt/β-catenin signaling pathway.

In the event of success, it has the potential to become a first-in-class therapy capable of modifying the course of the disease for the treatment of diabetes.

To date, the company has demonstrated the effectiveness of this program in preventing and reversing diabetes in in vivo models of type 1 diabetes.

During preclinical research, DiogenX has achieved a preliminary proof of concept with a significant increase in functional human beta cells, which are responsible for insulin production. Long-term exposure has been well tolerated in preclinical studies, demonstrating the safety of DiogenX’s approach targeting the Wnt/β-catenin pathway.

For the company, all of these data demonstrate the potential for clinical use both as a monotherapy and in combination with insulin injections and/or other therapies targeting pancreatic beta cells.

Type 1 diabetes is an autoimmune disease in which the insulin-producing pancreatic beta cells are destroyed by the immune system. This disease affects the metabolism of patients by influencing their ability to process and store glucose. Currently, there is no curative treatment for type 1 diabetes. It is estimated that 8.7 million people worldwide are living with type 1 diabetes, a number that is projected to reach 17 million by 2040.

Sources : DiogenX, Université Côte d’Azur

Healthtech Nice Côte d’Azur

Share it :

our events


IPAG Business School, 4 bd Carabacel à Nice
6 March 2024
Women TechEU : quelles perspectives européennes pour les femmes dans la tech ?
women tech eu
Nice - Centre Universitaire Méditerranéen
14 March 2024
neuroplanete 2024
Chambre de Commerce et d’Industrie Nice Côte d’Azur, 20 boulevard Carabacel, 06000 Nice
15 March 2024
Rencontres d’Affaires Select USA à Nice
Select USA Nice
Campus Sud des Métiers - 13 avenue Simone Veil à Nice
3 April 2024
Journée technologies immersives et apprentissage
technologies immersives nice
Hub de l'Innovation de la Métropole Nice Côte d'Azur
11 April 2024
Spring Tech 2024
spring tech nice
Allianz Riviera Nice
18 April 2024
Rencontres du CJD Nice : les intelligences artificielles au service du vivant ?
rencontres du CJD nice 18 avril 2024
21 July 2024
Arrivée du Tour de France 2024
Tour de france 2024
5 June 2025
Conférence des Nations Unies sur les Océans
Conférence sur les Océans - Nations Unies

Restons En Contact

Inscrivez Vous À Notre Newsletter

Keep in touch

Subscribe to our newsletter

Make an appointment

Leave us your contact details
to schedule a meeting with one of our experts.