{"id":5719,"date":"2020-12-06T17:53:17","date_gmt":"2020-12-06T16:53:17","guid":{"rendered":"https:\/\/www.investincotedazur.com\/?p=5719"},"modified":"2023-02-10T14:08:42","modified_gmt":"2023-02-10T13:08:42","slug":"sophia-antipolis-nicox-raises-e15-million-in-private-placement","status":"publish","type":"post","link":"https:\/\/www.investincotedazur.com\/en\/sophia-antipolis-nicox-raises-e15-million-in-private-placement\/","title":{"rendered":"Sophia Antipolis: Nicox raises \u20ac15 million in private placement"},"content":{"rendered":"

Nicox SA, based in Sophia Antipolis<\/strong>, an international ophthalmology company<\/a>, announced a financing through a private placement via the issuance of 3,529,565 new ordinary shares with gross proceeds of \u20ac15.0 million.<\/p>\n

The Company was previously financed to complete both the Mont Blanc Phase 3 trial for NCX 470 and the Mississippi Phase 2b trial for NCX 4251. \u00a0Proceeds from this financing extend the cash runway well beyond these key inflection points. \u00a0Nicox\u2019s principal shareholder HBM Healthcare Investments (SIX:HBMN), a leading, publicly listed healthcare investment fund was joined by new U.S. and European institutional investors in this financing.<\/p>\n

Michele Garufi, Chairman and Chief Executive Officer of Nicox,\u00a0<\/strong>said, \u201cWe are very pleased with the continued support from our long-term shareholder and would like to welcome the new specialist investors who participated in this financing.\u00a0 With a cash runway now well beyond the top-line results of two important trials of our lead product candidates, we are in the ideal position to capitalize optimally on the clinical results of both NCX 4251 and NCX 470 that are expected towards the end of next year.<\/em>\u201d<\/p>\n

Proceeds from this financing are not planned to be used to make payments on any of the Company’s debts, which are expected to be covered by licensing revenue.<\/p>\n

Cash Position<\/strong><\/p>\n

The Nicox Group had cash, cash equivalents and financial instruments of \u20ac39.0 million (excluding the proceeds of this financing) on November 30, 2020 and total financial debt of \u20ac18.7 million in the form of a bond financing agreement with Kreos Capital signed in January 2019 and a \u20ac2 million credit agreement with Soci\u00e9t\u00e9 G\u00e9n\u00e9rale and LCL, guaranteed by the French State, and granted in August 2020 in the context of the COVID-19 pandemic.<\/p>\n

Status of Key Development Programs<\/strong><\/p>\n

NCX 470<\/strong>, Nicox\u2019s lead clinical product candidate, a novel second-generation nitric oxide (NO)-donating bimatoprost analog, is being evaluated in the Mont Blanc and Denali Phase 3 clinical trials for the lowering of intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension. \u00a0Top-line results from Mont Blanc are currently expected in Q4 2021 and top-line results from Denali in Q4 2022. \u00a0The Denali trial is being jointly and equally financed by Nicox and Ocumension Therapeutics, our partner for the Chinese, Korean and South East Asian markets.\u00a0 Together Mont Blanc and Denali will support regulatory submissions in the U.S and China. \u00a0Results from the\u00a0Dolomites Phase 2<\/u>\u00a0clinical trial in patients with open\u2011angle glaucoma or ocular hypertension demonstrated statistical superiority of NCX 470 0.065% over the current standard of care, latanoprost 0.005%. \u00a0Nicox believes the IOP reduction from baseline at the three time points (8 AM, 10 AM and 4 PM) of 7.6 to 9.8 mmHg is the highest IOP reduction ever reported in an eye drop glaucoma clinical trial.\u00a0 The first Phase 3 trial, Mont Blanc, included an initial adaptive dose selection phase to evaluate two doses of NCX 470, 0.065% and 0.1%. \u00a0Following the completion of the adaptive design portion of Mont Blanc, the 0.1% dose of NCX 470 was selected for evaluation against latanoprost 0.005% in the second part of the Mont Blanc and in the Denali Phase 3 clinical trials.<\/p>\n

NCX 4251<\/strong>\u00a0is a novel patented ophthalmic suspension of fluticasone propionate nanocrystals and our second clinical program.\u00a0 The Mississippi Phase 2b clinical trial for the treatment of acute exacerbations of blepharitis is expected to be initiated later this month with top-line results currently expected in Q4 2021.\u00a0 If successful in meeting the primary endpoint previously agreed with the U.S. Food and Drug Administration (FDA), the Mississippi trial could represent the first of two pivotal trials needed to support the submission of a New Drug Application (NDA) in the U.S.\u00a0 NCX 4251 is the first product candidate developed as a targeted topical treatment of the eyelid margin in patients with acute exacerbations of blepharitis.\u00a0 The\u00a0Danube Phase 2<\/u>\u00a0demonstrated a statistically significant reduction in the composite score of key signs and symptoms of blepharitis at day 14 and also showed encouraging results in dry eye disease endpoints.<\/p>\n

We continue to closely watch the spread and impact of the COVID-19 pandemic.\u00a0 Some of the clinical trials indicated above have just started or will start in the near future, and any potential impact of the pandemic on them cannot be fully assessed at this time. \u00a0We do not currently anticipate major delays in our clinical timelines but we are monitoring the situation and will provide an update when needed.<\/p>\n

Main terms of the financing<\/strong><\/p>\n

The share capital increase without preferential rights, by issuance of 3,529,565 new ordinary shares, was reserved for subscription by French or foreign companies or mutual funds investing in the pharmaceutical biotechnology sector (soci\u00e9t\u00e9s ou fonds gestionnaires d\u2019\u00e9pargne collective de droit fran\u00e7ais ou de droit \u00e9tranger investissant dans le secteur pharmaceutique\/biotechnologique<\/em>) pursuant to the 7th<\/sup>\u00a0resolution of the Extraordinary General Meeting of Nicox dated June 30, 2020.<\/p>\n

The subscription price of the new shares has been set by the Board of directors on December 4 at \u20ac4.25 per new share representing a discount of 14.8% on the Volume Weighted Average Price (VWAP) over the last 3 trading days prior to pricing (equal to \u20ac4.99). \u00a0Following the completion of the capital increase, the 3,529,565 new shares will represent 10.5% of the issued share capital of the Company before the capital increase and 9.5% after the capital increase.\u00a0 The financing is expected to close on or about December 8, 2020, subject to the satisfaction of customary closing conditions.<\/p>\n

The impact of this share capital increase on (i)\u00a0the stake held in the Company\u2019s share capital by a shareholder holding 1%, and (ii)\u00a0the share of equity (on a consolidated and per-share basis) as at June 30, 2020, in each case calculated on a non-diluted and fully diluted basis,\u00a0i.e.<\/em>\u00a0taking into account the issuance of a maximum of 1,733,048 new shares upon (x)\u00a0exercise of all outstanding warrants and stock options, and (y)\u00a0the definitive acquisition of all free shares outstanding is as follows:<\/p>\n\n\n\n\n\n\n
<\/td>\nShareholder\u2019s interest<\/td>\nShare of equity (consolidated \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0and per-share basis)<\/td>\n<\/tr>\n
Before issue of 3,529,565 new shares<\/td>\n1.00%<\/td>\n\u20ac2.85<\/td>\n<\/tr>\n
After issue of 3,529,565 new shares (non-diluted basis)<\/td>\n0.90%<\/td>\n\u20ac2.95<\/td>\n<\/tr>\n
After issue of 3,529,565 new shares and of 1,733,048 new shares resulting from outstanding dilutive instruments (fully diluted basis)*<\/td>\n0.86%<\/td>\n\u20ac3.08<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

*The shares issuable from the additional contingent consideration payable to Aciex\u2019s former shareholders are not included in the above table as the Company considers it improbable that the conditions for the payment of this additional remuneration will be met.<\/em><\/p>\n

Directors and Executive Committee members of Nicox have agreed to certain customary lock-up arrangements with the Placement Agents on the shares they hold in Nicox for a 90-day period from the settlement date (subject to certain customary exemptions).<\/p>\n

Use of proceeds<\/strong><\/p>\n

The net proceeds from the issuance of the new shares are intended for working capital purposes.<\/p>\n

Listing of new shares<\/strong><\/p>\n

An application will be made for the admission to listing of the new shares on Euronext Paris.\u00a0 The settlement-delivery of the new shares is expected to take place on December 8, 2020.<\/p>\n

This financing does not require a listing prospectus submitted to the approval of the\u00a0French Autorit\u00e9 des March\u00e9s Financiers\u00a0<\/em>(AMF).<\/p>\n

Risks factors which are likely to have a material effect on Nicox\u2019s business are presented (i) in the 3rd<\/sup>\u00a0chapter of the \u2018Document d\u2019enregistrement universel, rapport financier annuel et rapport de gestion 2019<\/em>\u2019 filed with the French\u00a0Autorit\u00e9 des March\u00e9s Financiers<\/em>\u00a0(AMF) on March 6, 2020 which is available on Nicox\u2019s website (www.nicox.com<\/u><\/a>) and (ii) in the 4th<\/sup>\u00a0chapter of the half yearly financial report as of June 30, 2020, which is also available on Nicox\u2019s website.<\/p>\n

H.C. Wainwright & Co. and Bryan, Garnier & Co. are acting as joint lead placement agents for the financing.<\/p>\n

Composition of Nicox\u2019s Share Capital\u00a0<\/strong><\/p>\n

The table below reflects the positions to the best of the Company\u2019s knowledge.<\/p>\n\n\n\n\n\n\n\n\n\n\n\n
<\/td>\nAs of December 4, 2020<\/p>\n

Number of shares \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0and % of share capital<\/td>\n

After share capital increase<\/p>\n

Number of shares \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0and % of share capital<\/td>\n<\/tr>\n

HBM Healthcare Investments<\/td>\n2,383,808 \/ 7.12%<\/td>\n2,619,102 \/ 7.07%<\/td>\n<\/tr>\n
Orbimed<\/td>\n1,608,553 \/ 4.80%<\/td>\n1,608,553 \/ 4.34%<\/td>\n<\/tr>\n
Maven Investments Partners Limited<\/td>\n– \/ 0%<\/td>\n800,000 \/ 2.16%<\/td>\n<\/tr>\n
Banque Publique d’Investissement<\/td>\n384,300 \/ 1.15%<\/td>\n384,300 \/ 1.04%<\/td>\n<\/tr>\n
Michele Garufi<\/td>\n567,051 \/ 1.69%<\/td>\n567,051 \/ 1.53%<\/td>\n<\/tr>\n
Elizabeth Robinson<\/td>\n74,060 \/ 0.22%<\/td>\n74,060 \/ 0.20%<\/td>\n<\/tr>\n
Public<\/td>\n28,473,598 \/ 85.02%<\/td>\n31,352,169 \/ 84.69%<\/td>\n<\/tr>\n
Total<\/td>\n33,491,370 \/ 100%<\/td>\n37,020,935 \/ 100%<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

HBM Healthcare Investments, which held 2,383,808 shares as of December 4, 2020, representing 7.12% of the share capital, subscribed 235,294 shares as part of this transaction.<\/p>\n

About Nicox<\/strong><\/p>\n

Nicox S.A. is an international ophthalmology company developing innovative solutions to help maintain vision and improve ocular health.\u00a0 Nicox\u2019s lead program in clinical development is NCX 470, a novel, second-generation nitric oxide-donating bimatoprost analog, for lowering intraocular pressure in patients with glaucoma.\u00a0 The company is also developing NCX 4251, a proprietary formulation of fluticasone, for acute exacerbations of blepharitis.\u00a0 Nicox generates revenue from VYZULTA\u00ae<\/sup>\u00a0in glaucoma, licensed exclusively worldwide to Bausch + Lomb, and ZERVIATE\u2122 in allergic conjunctivitis, licensed in multiple geographies, including to Eyevance Pharmaceuticals, LLC, in the U.S. and Ocumension Therapeutics in the Chinese and in the majority of South East Asian markets.<\/p>\n

Nicox is headquartered in Sophia Antipolis, France, is listed on Euronext Paris (Compartment B: Mid Caps; Ticker symbol: COX) and is part of the CAC Healthcare, CAC Pharma & Bio and Next 150 indexes.<\/p>\n

For more information on Nicox, its products or pipeline, please visit:\u00a0www.nicox.com<\/u><\/a>.<\/u><\/p>\n","protected":false},"excerpt":{"rendered":"

Nicox SA, based in Sophia Antipolis, an international ophthalmology company, announced a financing through a private placement via the issuance of 3,529,565 new ordinary shares with gross proceeds of \u20ac15.0 million. The Company was previously financed to complete both the Mont Blanc Phase 3 trial for NCX 470 and the Mississippi Phase 2b trial for […]<\/p>\n","protected":false},"author":19,"featured_media":5720,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_mi_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0},"categories":[107],"tags":[],"acf":[],"yoast_head":"\nNicox raises \u20ac15 million in private placement - Invest in C\u00f4te d'Azur<\/title>\n<meta name=\"description\" content=\"Nicox, based in Sophia Antipolis, an international ophthalmology company, announced a financing through a private placement.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.investincotedazur.com\/en\/sophia-antipolis-nicox-raises-e15-million-in-private-placement\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nicox raises \u20ac15 million in private placement - 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